molecular hydrogen summit

Discover the latest innovations in Molecular Hydrogen Research

JOIN THE VIRTUAL SUMMIT: SEP 12 – OCT 12, 2024

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About the H2 Summit

The H2 Summit is a virtual online event bringing together leading researchers and the general public to explore the latest advancements in molecular hydrogen research. Our goal is to educate on molecular hydrogen’s therapeutic properties, spread awareness of molecular hydrogen as a medical gas, and advance the research by sharing industry insights and recent scientific papers. This summit is supported by the following entities:

Learn about the recent research

Why Hydrogen?

  • Molecular hydrogen (H2) or diatomic hydrogen is a tasteless, odorless, flammable gas.
  • H2 reduces oxidative stress and improves redox homeostasis partly mediated via the Nrf2 pathway, which regulates levels of glutathione, superoxide dismutase, catalase, etc.
  • H2, like other gaseous-signaling molecules (e.g. NO•, CO, H2S), modulates signal transduction, protein phosphorylation, and gene expression, which provides anti-inflammatory, anti-allergy, and anti-apoptotic protective effects
Human Studies
Disease Models
Peer-Reviewed Scientific Articles
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Confirmed Speakers

Prepare for a knowledge-packed journey at the H2 MHI Summit!

This summit has an impressive lineup of speakers who are leading academics, scientists, researchers, doctors, medical professionals, and more. Our highly qualified speakers are ready to share their research on the applications of molecular hydrogen from biomedicine and health, sports medicine and longevity, to food and agriculture. This is your exclusive opportunity to learn from the best experts and pioneers shaping the conversation.

Dr. John Kheir, MD., Harvard Medical School
Prof. Shigeo Ohta, PhD., Nippon Medical University
Prof. Mami Noda, PhD., RUDN University
Dr. Tyler W. LeBaron, MSc., PhD., Molecular Hydrogen Institute
Dr. Shucun Qin, MD, PhD., University of Shandong
Prof. Xunjun Sun, PhD., University of China
Prof. Xuemei Ma, PhD., Beijing University
Dr. Gagandeep Dhillon, MD, MBA., University of Maryland
Prof. Qianjun He, PhD., Shanghai Jiao Tong University
Prof. Kyu Jae Lee, M.D, PhD., Yonsei University
Dr. Dmitrii Atiakshin, MD. RUDN University
Dr. Oleg Medvedev, MD, PhD., Lomonosov Moscow State University
Dr. Kinji Ohno, MD., PhD., Nagoya University
Dr. Sergej Ostojić, MD., PhD., University of Agder
Dr. Jan Slezak, MD., PhD., Slovak Academy of Sciences
Prof. Duried Alwazeer, PhD., Igdir University
Dr. Eugeny Iv. Nazarov, MSc., PhD., International Association of Medical Gas Therapists
Prof Masaru Suzuki, MD., PhD., Keio University
Prof. Jiangang Long, PhD., Xi’an Jiaotong University
Prof. Majic Khazaei, MD., PhD., Mashhad University of Medical Sciences
Prof Guohua Song, PhD.
Prof. Youbin Wang, MD., Peking Union Medical College
Prof. Wanchao Yang, MD., PhD., Harbin Medical University
Prof. Li Ge, PhD., First Medical University
Prof. John Hancock, PhD.. University of the West of England
Prof. Dr. Shaoqing Yu, PhD., Tangji Hosiptal, School of Medicine
Prof. Oleh Pokotylo, PhD., Ternopil Ivan Pulyuj National Technical University
Prof. Emeritus Garth Nicolson, PhD, MD (H)., Institute of Molecular Medicine
Asst. Prof Darinka Korovljev, PhD., University of Novi Sad
Prof Dr Ram B Singh, MBBS, MD., Halberg Hospital and Research Institute
Nikola Todorović, Msc.., University of Novi Sad
Grace Russell, MSc., PhD., University of the West of England
Bob Settineri, MS., Sierra Productions Research
Dr. Mikhail Artamonov, MD PHD., MJA Health Care Network
Dr. Branislav Kura, RNDr., Ph.D., Slovak Academy of Sciences
Barbora Kaločayová, PhD., Slovak Academy of Sciences
Prof. Svetlana N. Radyuk, PhD.
Dr. Olga Pol, PhD., Autonomous University of Barcelona
Malte Ostendarp, PhD Candidate, University of Bremen
Yuxi Wei, MSc Candidate, University of British Columbia
Jiayuan Zhai, PhD Candidate., Harbin Medical University
Dejan Javorac, MSc., University of Novi Sad
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If you’ve ever asked:

  • Is hydrogen water a scam?
  • What are the benefits of molecular hydrogen?
  • What is molecular hydrogen?
  • What is molecular hydrogen?
  • Is hydrogen good for you?
  • What are the safety concerns?

Then this summit is for you!

The H2 Summit is designed for a wide range of attendees, from professionals to enthusiasts, interested in learning about the potential of molecular hydrogen. Whether you’re a healthcare provider, researcher, or simply curious about the latest scientific advancements, this summit offers invaluable insights for everyone.

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Here’s who should join us:
  • Health and Wellness Enthusiasts
  • Researchers and
    Academics
  • Healthcare Professionals
  • Sales Associates
  • General Public
  • Anyone and Everyone

Presentation Highlights

Molecular hydrogen (H2) has multiple properties such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties, having wide variety of beneficial outcomes. Effects of H2 are often slow to show the effects. The amount of H2 in drinking water is far less than that of inhalation. H2, especially in drinking water, can be used for therapy but rather for maintenance and improvement of the health condition or prevention of disorders. From mechanistic point of view, the problem is that pharmacokinetics of H2 in drinking water is largely unknown, especially in the brain. This video shows examples of effects of H2 by long-term intake of H2. Also, the mechanism is discussed from homeostatic and endocrinical point of view, trying to understand why H2 has such a wide variety of effects. Due to the endocrinological effects, H2 has a corrective effect on the neuro-immuno-endocrine system and determines the functioning of the body’s homeostatic system. It will be plausible why intake of H2 helps health and slow aging.

Hydrogen molecules have a wide-spectrum anti-oxidation and anti-inflammation effect, and exhibit a clear biological effects and high biosafety in treatment of many inflammation-related diseases. Hydrogen therapy becomes an emerging and promising therapeutic strategy. However, hydrogen medicine currently faces three major problems, including (1) what is the fundamental principle of hydrogen therapy; (2) how to detect hydrogen molecules in vivo; (3) how to deliver hydrogen molecules to the focus. In an attempt to address these issues, our research group does researches about principle exploration, tool development and materials application, harvesting a series of innovative achievements, mainly including: (1) we have discovered the biological target of hydrogen molecules, and revealed the fundamental principles of H2 anti-inflammation, anti-cancer and anti-senescence; (2) we have developed the first bio-probe of H2, and testified high bio-barriers-crossing capability of H2; (3) we have developed a series of novel H2-delivering biomaterials to enhance H2 delivery efficacy and applied these materials for treatment of major diseases.[1-10] This report will present the related research advances achieved by us in the recent years.

氢分子具有广谱抗炎抗氧化效应，在炎症相关的众多重大疾病中展现出明确的生物学效应和较高的生物安全性。氢气治疗成为一种新兴的、且非常有应用前景的治疗策略。但目前氢医学面临着三大难题：（1）氢气治疗的原理是什么；（2）如何在体内检测氢气；（3）如何向体内递送氢气。针对这三大难题，本课题组在原理探究、工具开发、材料应用三个方面开展研究，取得了系列创新性研究成果，主要包括：（1）发现了氢分子生物学靶点，揭示了氢分子抗炎、抗癌、抗衰的基本原理；（2）开发了首例氢分子生物探针，证实了其高的跨生物屏障能力；（3）开发了系列新型氢递送医用材料，提高了氢气递送效率，并应用于重大疾病治疗。本报告将汇报本课题组近年来在这三个方面的研究进展。[1-10]

Keywords: Hydrogen medicine; Nanomedicine; Drug delivery; Anti-inflammation

References

  • Qingqing Xu, Shengqiang Chen, Lingdong Jiang, Chao Xia, Lingting Zeng, Xiaoqing Cai, Zhaokui Jin, Shucun Qin, Wenjiang Ding, Qianjun He, Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing, National Science Review 2023, 10, nwad063.
  • Shengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, Xishen Xu, Zhaokui Jin, Qianjun He, Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing, Nature Communications 2022, 13, 5684.
  • Bin Zhao, Lingting Zeng, Danyang Chen, Songqing Xie, Zhaokui Jin, Guanglin Li, Wei Tang, Qianjun He, NIR-photocatalytic regulation of arthritic synovial microenvironment, Science Advances 2022, 8, eabq0959.
  • Wanjun Gong, Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Danyang Chen, Zhaokui Jin, Shucun Qin, Zhiqiang Yu, Qianjun He, An activity-based ratiometric fluorescent probe for in vivo real-time imaging of hydrogen molecules, Angewandte Chemie International Edition 2022, 61, e202114594.
  • Yangsen Xu, Mingjian Fan, Wenjuan Yang, Yonghao Xiao, Lingting Zeng, Xiao Wu, Qinghua Xu, Chenliang Su, Qianjun He, Homogenous carbon/potassium-incorporation strategy for synthesizing red polymeric carbon nitride capable of near-infrared-photocatalytic H2 production, Advanced Materials 2021, 33, 2101455.
  • Danyang Chen, Zhaokui Jin, Bin Zhao, Yingshuai Wang, Qianjun He, MBene as a theranostic nanoplatform for photocontrolled intratumoral retention and drug release, Advanced Materials 2021, 33, 2008089.
  • Bin Zhao, Yingshuai Wang, Xianxian Yao, Danyang Chen, Mingjian Fan, Zhaokui Jin, Qianjun He, Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst, Nature Communications 2021, 12, 1345.
  • Jin Meng, Zhaokui Jin, Penghe Zhao, Bin Zhao, Mingjian Fan, Qianjun He, A multistage assembly/disassembly strategy for tumor-targeted CO delivery, Science Advances 2020, 6, eaba1362.
  • Yingshuai Wang, Tian Yang, Qianjun He, Strategies for engineering advanced nanomedicines for gas therapy of cancer, National Science Review 2020, 7, 1485.
  • Penghe Zhao, Zhaokui Jin, Qian Chen, Tian Yang, Danyang Chen, Jin Meng, Xifeng Lu, Zhen Gu, Qianjun He, Local generation of hydrogen for enhanced photothermal therapy, Nature Communications 2018, 9, 4241.

Coming Soon

Coming Soon

After Professor Shigeo Ohta’s team discovered that trace amounts of hydrogen have powerful medical effects in 2007, the biomedical community has conducted a large number of exploratory studies on the medical effects of hydrogen. Hydrogen can selectively neutralize hydroxyl radicals, resulting in antioxidant damage and alleviating inflammatory damage. Hydrogen medicine has three outstanding characteristics, namely significant human safety, selective antioxidant effects, and strong biological tissue diffusion ability. These characteristics make hydrogen have great potential for application in daily health fields, such as exercise assistance, disease treatment assistance, and health promotion. This speaker will introduce the above content, which is suitable for non-professional peers who are concerned about hydrogen health, hydrogen health medicine enthusiasts, hydrogen health product marketers, and ordinary users.

Introduction: While heart transplantation has become a standard treatment for chronic heart failure, the damage caused by ischemia-reperfusion injury to the heart, especially after cold ischemic storage and subsequent reperfusion, is a critical aspect of restoring heart function. Reperfusion with warm, oxygenated blood leads to an increase in reactive oxygen species (ROS), including highly damaging nitrosyl and •OH radicals. Additionally, factors such as anesthetics, hyperoxia used during anesthesia, electric shocks, during  defibrillations contribute to ROS formation, presenting an independent risk factor for mortality. Extracorporeal circulation (ECC) exacerbates oxidative stress throughout the body and contributes to transplantation complications and failures. This results in the formation of lipid peroxides and other oxidative stress products that hinder ATP production by mitochondria.

Methods: During simulated heart transplantation, the administration of hydrogen gas may mitigate oxidative stress by selectively reducing hydroxyl radicals, decreasing lipid peroxidation, inflammation, and the decreased activity of native antioxidant enzymes. This leads to improved resumption of pumping activity in pig hearts stored under cold ischemia for three hours and subsequently implanted. Furthermore, it reduces the oxidative stress caused by extracorporeal circulation.

Results: Adding 4% hydrogen gas to inspiratory gases and ECC before heart retrieval from the donor, during its cold storage, after its implantation and subsequent warming during reperfusion significantly decreased oxidative stress markers (malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase), markers of ischemia (creatine kinase), inflammation (tumor necrosis factor-alpha), and whole-body peroxidation. Hydrogen-treated swine also exhibited significantly less severe ventricular fibrillation than controls.

Conclusion: With proper precautions, hydrogen can be safely administered through conventional ventilators and ECC oxygenators. It represents a complementary therapy easily incorporated into current transplantation techniques.

Funding: This research was funded by grants from Slovak Research and Development Agency (APVV-0241-11, APVV-15-0376, APVV-19-0317), grant from the Slovak Academy of Sciences (VEGA 2/0092/22 and  2/0063/18), and grant from Ministry of Health of The Slovak Republic (2019/4-CEMSAV-1).

Co-authors: Dr. Branislav Kura, PhD

Molecular hydrogen (H2, dihydrogen) has emerged as a novel medical gas with applications spanning various biomedical domains, particularly within neurology and neuroscience. Its therapeutic potential has been explored in conditions ranging from Parkinson’s disease and stroke to traumatic brain injury and cancer, with both preclinical and clinical studies highlighting its protective and therapeutic effects. However, the specific mechanism of action of dihydrogen in the brain remains incompletely understood. This invited lecture aims to summarize and discuss the hydrogen-induced modulation of several neurotransmitters and brain-specific biomolecules/metabolites, shedding light on its role in both organ-specific and systemic pathways relevant to health and disease.

Keywords: dihydrogen, brain, MR spectroscopy, glutamate/GABA-glutamine, SCFAs

Sergej M. Ostojic 1 2 3
1 Applied Bioenergetics Lab, University of Novi Sad, Serbia
2 Department of Nutrition and Public Health, University of Agder, Norway
3 Faculty of Health Sciences, University of Pecs, Hungary

Food is prone to many spoilage phenomena, causing undesirable changes in its quality, loss of nutritive value, and shortening its shelf life. Our team studied the effect of hydrogen application in different food processes on the quality attributes of products. In food drying, including hydrogen in the drying atmosphere allowed for the protection of the nutritional and sensory properties of the product (apricot and apple). Additionally, incorporating hydrogen in the atmosphere of the food package allowed for the protection of the physico-chemical and nutritional properties of various foods, including strawberries, fish, and fresh cheese, with an extended shelf life. The results show that the use of hydrogen in food processes can be useful for the preservation of freshness and quality attributes of foods. 

Biogenic amines form serious health problems in fermented and high-protein foods. Our team revealed that using hydrogen-rich water in the butter washing process, in the fermentation of vegetables, as well as the use of hydrogen gas in the packaged fish atmosphere and minced beef, could limit the formation of biogenic amines during the storage period. On the other hand, heavy metals are cancerogenic contaminants of foods. Our team revealed that the use of hydrogen-rich water in the washing process of foods, such as butter, allowed to decrease the heavy metal content in the final product. The results suggest that applying hydrogen in its gas or hydrogen-rich water forms can enhance the final product’s biogenic amine and heavy metal safety.

The bio-accessibility and bio-availability are fundamental steps in utilizing nutrients in the metabolic processes. Our team revealed that hydrogen-rich water can enhance the extraction of various components from various plant materials. The extraction of phenolic substances, flavonoids, anthocyanins, pigments, organic acids, reduced sugars, amino acids, ascorbic acid, and antioxidants was significantly increased when hydrogen-rich water was used instead of normal water in the extraction process. The extraction of these nutrients and phytochemicals was better at 35⁰C than 25⁰C. The results propose that drinking hydrogen-rich water at room temperature after eating fruits, vegetables, meats, and other foods may enhance the bio-accessibility and bio-availability of nutrients and vitamins.

+ Many More!

Here’s what you can expect to learn:

  • Introduction to Hydrogen Medicine: Explore the development and future mission of hydrogen medicine.
  • Therapeutic Mechanisms: Understand the anti-oxidation, anti-inflammatory, and anti-allergic effects of molecular hydrogen.
  • Administration Methods: Learn about different methods of ingesting hydrogen, such as inhalation, drinking, and topical applications.
  • Cardiac Protection: Discover how hydrogen gas can protect the heart from ischemia-reperfusion injury.
  • Anti-aging Properties: Examine how hydrogen can slow aging by improving metabolic and homeostatic functions.
  • Neuroprotection: Investigate hydrogen’s potential in treating neurological conditions like Parkinson’s disease and traumatic brain injury.
  • Cancer Therapy: Assess the efficacy of hydrogen-rich water in reducing tumor growth in colorectal cancer models.
  • Sports Medicine: Review the benefits of hydrogen-rich water in accelerating recovery from sports injuries.
  • Oxidative Stress Reduction: Learn how hydrogen decreases oxidative stress in various medical conditions.
  • Inflammatory Diseases: Study the anti-inflammatory properties of hydrogen and its application in diseases like arthritis.
  • Radiation Protection: Explore hydrogen’s potential in protecting against radiation-induced damage.
  • Food Preservation: Understand how hydrogen can improve the nutritional and sensory qualities of food products.
  • Microbial Hydrogen Economy: Delve into hydrogen’s role in maintaining intestinal health through microbial balance.
  • Lung Health: Learn about hydrogen’s anti-fibrotic effects in lung diseases.
  • Allergic Rhinitis: Discover the therapeutic effects of hydrogen-rich saline in treating allergic rhinitis.
  • Mental Health: Examine how hydrogen can alleviate symptoms of anxiety, depression, and cognitive decline.
  • Stem Cell Priming: Understand how molecular hydrogen can enhance the effectiveness of stem cell therapies.
  • Hydrogen Nanobubbles: Investigate the use of hydrogen nanobubbles in protecting the heart from oxidative damage.
  • Blood Pressure Management: Review the effects of hydrogen-rich water on blood pressure variability and hypertension.
  • Quality of Life in the Elderly: Learn about hydrogen inhalation therapy to improve health and quality of life in elderly patients.

And much much more!

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Benefits of attending for the General Public

  • Learn from Experts: Understand cutting-edge research in accessible language.
  • Combat Misinformation: Get accurate information from leading researchers.
  • Gain Understanding: Hear the latest research and insights.
  • And more!
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Benefits of attending for Academics

  • Global Stage: Share your research with a global audience.
  • Increase Paper Citations: Enhance the visibility of your work.
  • Stay Updated: Hear the latest research and insights.
  • And more!
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FAQ’s

There are a few different ticket options. The free ticket gives you access to select recorded presentations for 24 hours. There are also paid ticket options that give you access to more presentations for 30 days. You can choose a ticket that best meets your needs on the tickets page.

There is a free option with 24 access to some recordings. There are also VIP tickets you can upgrade to with 30-day access to all recordings. Presenters will automatically be upgraded to VIP ticket status for both conferences. Students and/or researchers can access the VIP tickets at a discounted price. Get tickets here. If you are a researcher/academic, learn how to become a speaker here.

The event is virtual and takes place on the MHI learning platform. You will get access on the day of the event to all of the recorded content on the learning platform. You can watch the videos in any order at your own pace. We recommend you watch the videos in the order they are presented. Discussions and comments will be available on most videos.

After registering, you will be emailed a link to the event. We recommend you add this event to your calendar. You can also go to the MHI website and “sign in” on the day of the event to access the content.

We recommend accessing the event from your computer. You will need internet access, but because it is not a live event, you will not need to worry about “missing out” on buffering or anything like that. You can watch the pre-recorded sessions at your own pace. If you need more time or are unable to attend the day of the summit, we recommend upgrading to the VIP tickets so that you have the full 30 days to watch the recordings since there are so many great presentations. There are two payment options for the VIP tickets, and you can choose the one that is within your budget/category. See tickets here.

For help during the event (or before/after), you can email us at events@molecularhydrogeninstitute.org.

The event begins at 9 am Mountain Daylight Time (MDT) / UTC-6. You may want to be aware of this, as the free ticket only has 24 hour access from this time.

Yes, all presentations are pre-recorded. Upgraded VIP ticket holders will be able to access the recordings for 30 days after the event. Get your tickets here.

We do have discussions enabled on many of the presentations so you can ask questions and add to the discussions. The beauty of this event is that you can attend when it is convenient for you. Because this is a pre-recorded event, we do not have any specific networking activities planned outside of the discussion options.

As a nonprofit, MHI aims to provide non-biased information during the event. Because of this, we decided not to have any corporate sponsors.

Full recordings or downloading videos to upload on your own sites are not permitted. You are allowed to record up to one minute of the presentations to promote the event on social media. Please tag MHI (Instagram: @h2mhi or Facebook: @molecularhydrogeninstitute) in your posts and avoid promoting any products within the shared clips.

Choose your ticket

Come participate in the first-ever H2 MHI Summit. There are several ticket options, choose the one that best works for you!

This is a two-in-one virtual conference that you do not need to travel for. Hear about the latest research from the top-tier hydrogen scientists, researchers, and medical professionals. In this virtual event, you won’t have to worry about internet glitches, waiting for the presenter to begin, or missing anything when you step away. Because of the virtual format, presentations are pre-recorded, meaning you can watch at double speed (or half speed), pause, or rewind.

Virtual Limited (CLOSED)

  • 24-hour limited virtual access to
  • Academic Symposium
  • General Public Conference
  • 6+ hours of pre-recorded content
  • 15 speakers
  • 18 presentations
  • PDF printable program

Access ends Sep 13 at 9am MT/UTC-6

$97 FREE (CLOSED)

Virtual VIP

  • 30-day virtual access
    (September 12-Oct 12) to
  • Academic Symposium
  • General Public Conference
  • 20+ hours of pre-recorded content
  • 40+ speakers
  • 45+ presentations
  • PDF printable program
  • Certificate of Attendance

Access ends Oct 12 at 9am MT/UTC-6

$297 $27

Virtual Premium (CEU)

Learn about CEUs

  • 90-day virtual access to
  • Academic Symposium
  • General Public Conference
  • 20+ hours of pre-recorded content
  • 40+ speakers
  • 45+ presentations
  • PDF printable program
  • Certificate of Attendance
  • 1 CEU from SUU

Access ends Dec 12 at 9am MT/UTC-6

$697 $200

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Discover the latest innovations in Molecular Hydrogen Research

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